PUREVO: the pharma centrifuge that meets highest hygienic standards
Centrifuges are often the centerpiece in the production of sterile and other active pharmaceutical PUREVO pharma centrifuge from Andritz Separation ensures effective solid-liquid-separation in a clean and sterile atmosphere.
One of the biggest risks during surgery is that of an infection. To reduce this risk for the patient, it is common practice to administer an intravenous antibiotic shortly before the anesthetic. These have to be sterile like all intravenous injections and also some other types of drugs. To meet these high standards, validated production processes and machines are required in order to ensure a clean atmosphere and prevent any kind of contamination.
The new PUREVO pharma centrifuge from Andritz Separation, one of the leading manufacturers of horizontal peeler centrifuges that are often the centerpiece in the production of sterile and other active pharmaceutical ingredients, ensures effective solid-liquid-separation in a clean and sterile atmosphere.
The newly developed cleaning procedure consists of a CIP stage, which is followed by the SIP (sterilization in place) procedure. In the upstream CIP stage, the entire process area is flooded with cleaning liquid, and a specific rotational speed sequence is run to remove nearly all impurities. Any remaining impurities will be removed in the final cleaning stage with the aid of cleaning nozzles, which also reach the less easily accessible areas.
If the CIP cleaning sequence is not enough, the PUREVO pharma centrifuge can also be sterilized. Sterilization means that a temperature of 120 °C minimum must be reached in every part of the centrifuge for a certain period of time in order to destroy all sources of contamination. To achieve this, not only is the process housing of the centrifuge flushed out with hot steam (T > 120 °C) but also the housing sealing, which is much more difficult to access, in order to ensure that the required standards can be fulfilled even at the coldest point. In addition to specification of this process, the entire mechanical design has been modified to meet the required temperature and pressure levels as well as complying with the existing guidelines
Furthermore, with the improvements already implemented, like replacement of all hydraulic drives by electric and/or pneumatic drives (including clean exhaust air handling) or the further developed clean room installation concept, the PUREVO pharma centrifuge meets the highest hygienic standards.
